Abstract: Voxel-based soft robots (VSRs) present a promising avenue for developing artificial organisms with lifelike intelligence. However, the vast design spaces and expensive evaluations substantially challenge their design optimization. Here we develop MISCO, a novel evolutionary framework empowered by deep generative models to optimize VSR designs with theoretical guarantees. MISCO integrates an estimation-of-distribution algorithm with a meticulously designed variational autoencoder featuring multi-task learning, position awareness, and inter-voxel signaling. These key components enhance the representational capacity of VSR morphologies and facilitate highly efficient sampling and optimization of morphological distributions. We provide theoretical guarantees for MISCO's asymptotic convergence to globally optimal designs, alongside a favorable convergence rate. Extensive simulated experiments further demonstrate MISCO's exceptional effectiveness in navigating vast design spaces, evolving high-performing VSRs for diverse tasks while flexibly balancing optimization efficiency and morphological diversity. Being validated both empirically and theoretically, MISCO represents a step change towards more scalable and reliable soft robot development.
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