arXiv:2605.01189v3 Announce Type: replace
Abstract: Clinical AI adoption is hindered by the black-box/grey-box nature of high-performing models, which lack the ontological grounding and narrative transparency required for professional-level explainability. We present NEURON, a neuro-symbolic system designed to enhance both predictive reliability and clinical interpretability. NEURON integrates SNOMED CT ontology-informed structural representations with machine learning models to bridge the gap between raw data and medical nomenclature. To facilitate human-aligned interaction, the system utilizes a Retrieval-Augmented Generation (RAG) grounded Large Language Model (LLM) layer to synthesize SHAP feature attributions and patient-specific clinical notes into coherent, natural-language explanations. Validated on the MIMIC-IV dataset for Acute Heart Failure mortality prediction, NEURON improved the AUC from 0.71-0.74 to 0.74-0.77 and substantially outperformed SHAP-based explanations in human-aligned metrics (0.807 vs. 0.558). Our results demonstrate that NEURON offers a robust, scalable engineering solution for deploying trustworthy, human-centered connected health applications.
Abstract: Clinical AI adoption is hindered by the black-box/grey-box nature of high-performing models, which lack the ontological grounding and narrative transparency required for professional-level explainability. We present NEURON, a neuro-symbolic system designed to enhance both predictive reliability and clinical interpretability. NEURON integrates SNOMED CT ontology-informed structural representations with machine learning models to bridge the gap between raw data and medical nomenclature. To facilitate human-aligned interaction, the system utilizes a Retrieval-Augmented Generation (RAG) grounded Large Language Model (LLM) layer to synthesize SHAP feature attributions and patient-specific clinical notes into coherent, natural-language explanations. Validated on the MIMIC-IV dataset for Acute Heart Failure mortality prediction, NEURON improved the AUC from 0.71-0.74 to 0.74-0.77 and substantially outperformed SHAP-based explanations in human-aligned metrics (0.807 vs. 0.558). Our results demonstrate that NEURON offers a robust, scalable engineering solution for deploying trustworthy, human-centered connected health applications.
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